Cockayne syndrome (CS) is a rare genetic progeroid disorder characterized by growth and development defects, severe cutaneous photosensitivity, cachectic dwarfism, progressive neurological dysfunction, and precocious aging.
The molecular basis of these clinical traits are still unknown. Cells derived from CS patients present as pathological hallmarks excessive oxidative stress, intense...
The higher cancer susceptibility of severe obese people and the relationship among diet, obesity and gut microbiota are well established. However, the molecular mechanisms that underlie this crosstalk are still under investigation. A chronic low-grade inflammation, oxidative stress and circulating microbial metabolites are common features in obese people. In order to find predictive...
Life is the interplay between structure and energy, and Mitochondria, recognized as the cell's powerhouse, have been probably essential for the evolution of multicellular organisms . Mitochondria are best known as those organelles where the energy required for life is produced in the form of ATP molecules with the highest effectiveness, by the process called oxidative phosphorylation (OXPHOS)....
