Several lines of evidence show that an increase in body fat mass is linked to oxidative stress and that the accumulation of radical oxygen species (ROS) contributes to develop the metabolic syndrome.
ROS induce DNA damage with a consequent activation of DNA damage response, an orchestrated set of proteins which trigger a systemic inflammatory response.
Mice defective in DNA damage processing...
Shwachman-Diamond Syndrome (SDS) is a ribosomopathy with a wide spectrum of clinical presentations [1] associated with the loss of function of Shwachman-Bodian-Diamond Syndrome (SBDS) protein [2] and as we described for the first time [3], the Elongation Factor-Like 1 (EFL1). Together, these proteins remove the anti-associationfactor eIF6 from the surface of the pre-60S ribosomal subunit to...
Manufactured nanomaterials (MNMs) are extensively produced worldwide and used in many different consumer products due to their unique physico-chemical properties. It is obvious that, as the properties change, unwanted properties (i.e. toxicity) are to be expected as well. While the production of MNMs is growing exponentially, research into the toxicological impact and possible hazard of...
