Steroid hormones act via specific receptors that activate gene transcription; hydroxysteroid dehydrogenases (HSDs) are responsible for pre-receptor regulation of steroid hormone activity. Indeed, 17$\beta$ hydroxysteroid dehydrogenase (17$\beta$-HSD) modulate the biological potency of estrogens and androgens by reducing the (inactive) keto-form or oxidizing the (active) hydroxy-form at...
Nuclear Magnetic Resonance (NMR) spectroscopy has long emerged as a powerful tool for understanding metabolic process in living systems. Over the last decade, metabolomics has been considered as a well-established approach to elucidate metabolism and its mechanism. Formally defined as “the quantitative measurement of the multi-parametric metabolic response of living systems to...
The self-assembling of the amyloid β (Aβ) peptide into neurotoxic aggregates is considered a central event in the pathogenesis of Alzheimer’s Disease (AD). Based on the “amyloid hypothesis” much efforts have been devoted in designing molecules able to halt disease progression by inhibiting Aβ self-assembly. By combining biophysical, biochemical and computational techniques, we investigated the...
