Conveners
Sessione: 2
- Angela Stefanachi (Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari)
X-ray Crystallography plays a crucial role in the structural investigation of drugs and provides a fundamental support for drug design and quality control in the drug development process [e.g., monitoring and quality check of Active Pharmaceutical Ingredient (API) and finished products]. Depending on the size of crystals (i.e., fraction of mm or a few $\mu$m), the kind of source (i.e., X-ray...
Microreactor technology and flow chemistry could play an important role in the development of green and sustainable synthetic processes.1 In this presentation, some recent relevant examples in the field of flash chemistry, catalysis, hazardous chemistry and continuous flow processing of metallated species are described.2 Selected examples highlight the role that flow chemistry could play in...
Parkinson’s disease (PD) and α-synucleinopathies are characterized by the progressive loss of neuronal cells and the decline of cognitive and motor functions. Oxidative stress, dyshomeostasis of metal ions and α-synuclein (αSyn) should be key factors in the development of these disorders1,2. Moreover, the aggregation of αSyn is a crucial event in the pathogenesis of α-synucleinopathies....
Tubular aggregates myopathy (TAM) is a hereditary ultra-rare muscle disorder, actually without a cure, characterized by progressive weakness, myalgia or myastenic features. Biopsies from patients with TAM show the presence of tubular aggregates (TAs) originated from sarcoplasmic reticulum (SR) (1). TAs formation is triggered by functional consequences due to disruption in the SR-T- tubule...
