Joined Workshop between the Institute of Crystallography-CNR (IC-CNR) and the Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, The Netherlands

Contribution List

2. Welcome and intro IC-CNR & M4I

Dr Cinzia Giannini (IC-CNR) , Prof. Ron Heeren (M4I)

07/03/2023, 13:00

Session

3. Machine learning-based prediction of hERG-mediated cardiotoxicity: a structure-based investigation

Dr Giuseppe Felice Mangiatordi (IC-CNR (Bari))

07/03/2023, 13:15

Session

Giuseppe Felice Mangiatordi(1) Pietro Delre(1,2) Teresa Maria Creanza(3), Nicola Ancona,(3) Giovanni Lentini,(4) Michele Saviano(1).

1. Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via G. Amendola 122/O, 70126 Bari.
2. Chemistry Department, University of Bari “Aldo Moro”, via E. Orabona, 4, I-70125 Bari, Italy.
3. CNR - Institute of Intelligent Industrial...

16. Pushing the limits of sample vitrification

Dr Navya Premaraj (M4I)

07/03/2023, 13:45

Session

Cryogenic Electron Microscopy (cryo-EM) is a powerful imaging technique for visualizing molecular structures with unprecedented detail. To prepare samples for cryo-EM a process called vitrification is typically used which involves rapidly freezing a thin layer of sample to create a non-crystalline solid. Plunge freezing is currently the most commonly method used method for preparing samples...

18. Beyond the “Amyloid Hypothesis”? Rescuing proteostasis in Alzheimer’s Disease”

Dr Danilo Milardi (IC-CNR (Catania))

07/03/2023, 14:15

Session

Danilo Milardi
(1)Institute of Crystallography, Consiglio Nazionale delle Ricerche, 95125, Catania, Italy

Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population. The estimated global prevalence of AD in 2015 was 46 million with an incidence rate in 2050 of 131 million. In the absence of medical advancements to prevent, slow down, or stop the disease, there...

8. Towards more dose efficient cryogenic electron microscopy of biological samples

Dr Yue Zhang (M4I)

07/03/2023, 15:00

Session

Cryo-electron microscopy (cryo-EM) has become an indispensable tool for structural biologists studying the relationship between structure and function of various biomolecules. Recent advancements in transmission electron microscopy (TEM) hardware and data processing software have enabled atomic-level resolution for single particle cryo-EM. However, achieving near-atomic resolution for smaller...

7. Insights on the molecular and structural basis of human dystroglycanopathies

Sonia Covaceuszach (CNR-IC (Trieste))

07/03/2023, 15:30

Session

Cassetta A(1), Longo F(1), Sciandra F(2), Bozzi M(2,3), Bigotti MG,(4) Hübner W(5), Brancaccio A(2), Covaceuszach S(1)

1 Istituto di Cristallografia - Trieste
2 Istituto di Chimica del Riconoscimento Molecolare - Roma
3 Università Cattolica del S. Cuore, Roma
4 University of Bristol, UK
5 University of Bielefeld, Germany

Dystroglycanopathies are neuromuscular disorders associated...

17. Structural insight into mycobacterial protein secretion

Dr Ye Gao (M4I)

07/03/2023, 16:00

Session

Mycobacteria tuberculosis employs Type 7 Secretion System (T7SS) to secrete effector proteins to help escape from the host immune system. There are five gene clusters named ESX-1 to ESX-5 belonging to T7SS in M. tuberculosis. ESX-1 is the first identified ESX system and has been shown to be essential for phagosome rapture. Secreted proteins have to cross both membranes of the bacterium. ESX-1...

1. Discussion and Conclusions

07/03/2023, 16:30

Speakers: Dr. Cinzia Giannini (IC-CNR) and Prof Ron Heeren (M4I)

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