Joined Workshop between the Institute of Crystallography-CNR (IC-CNR) and the Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, The Netherlands

Session

Session

7 Mar 2023, 13:00

Webinar

Conveners

Session: 1

• Raimond Ravelli (M4I)
• Dritan Siliqi (IC-CNR)

Contribution list Timetable

2. Welcome and intro IC-CNR & M4I

Dr Cinzia Giannini (IC-CNR) , Prof. Ron Heeren (M4I)

07/03/2023, 13:00

3. Machine learning-based prediction of hERG-mediated cardiotoxicity: a structure-based investigation

Dr Giuseppe Felice Mangiatordi (IC-CNR (Bari))

07/03/2023, 13:15

Giuseppe Felice Mangiatordi(1) Pietro Delre(1,2) Teresa Maria Creanza(3), Nicola Ancona,(3) Giovanni Lentini,(4) Michele Saviano(1).

1. Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via G. Amendola 122/O, 70126 Bari.
2. Chemistry Department, University of Bari “Aldo Moro”, via E. Orabona, 4, I-70125 Bari, Italy.
3. CNR - Institute of Intelligent Industrial...

16. Pushing the limits of sample vitrification

Dr Navya Premaraj (M4I)

07/03/2023, 13:45

Cryogenic Electron Microscopy (cryo-EM) is a powerful imaging technique for visualizing molecular structures with unprecedented detail. To prepare samples for cryo-EM a process called vitrification is typically used which involves rapidly freezing a thin layer of sample to create a non-crystalline solid. Plunge freezing is currently the most commonly method used method for preparing samples...

18. Beyond the “Amyloid Hypothesis”? Rescuing proteostasis in Alzheimer’s Disease”

Dr Danilo Milardi (IC-CNR (Catania))

07/03/2023, 14:15

Danilo Milardi
(1)Institute of Crystallography, Consiglio Nazionale delle Ricerche, 95125, Catania, Italy

Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population. The estimated global prevalence of AD in 2015 was 46 million with an incidence rate in 2050 of 131 million. In the absence of medical advancements to prevent, slow down, or stop the disease, there...