Joined Workshop between the Institute of Crystallography-CNR (IC-CNR) and the Maastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, The Netherlands

Session

Session

7 Mar 2023, 15:00

Webinar

Conveners

Session: 2

• Dritan Siliqi (IC-CNR)
• Raimond Ravelli (M4I)

Contribution list Timetable

8. Towards more dose efficient cryogenic electron microscopy of biological samples

Dr Yue Zhang (M4I)

07/03/2023, 15:00

Cryo-electron microscopy (cryo-EM) has become an indispensable tool for structural biologists studying the relationship between structure and function of various biomolecules. Recent advancements in transmission electron microscopy (TEM) hardware and data processing software have enabled atomic-level resolution for single particle cryo-EM. However, achieving near-atomic resolution for smaller...

7. Insights on the molecular and structural basis of human dystroglycanopathies

Sonia Covaceuszach (CNR-IC (Trieste))

07/03/2023, 15:30

Cassetta A(1), Longo F(1), Sciandra F(2), Bozzi M(2,3), Bigotti MG,(4) Hübner W(5), Brancaccio A(2), Covaceuszach S(1)

1 Istituto di Cristallografia - Trieste
2 Istituto di Chimica del Riconoscimento Molecolare - Roma
3 Università Cattolica del S. Cuore, Roma
4 University of Bristol, UK
5 University of Bielefeld, Germany

Dystroglycanopathies are neuromuscular disorders associated...

17. Structural insight into mycobacterial protein secretion

Dr Ye Gao (M4I)

07/03/2023, 16:00

Mycobacteria tuberculosis employs Type 7 Secretion System (T7SS) to secrete effector proteins to help escape from the host immune system. There are five gene clusters named ESX-1 to ESX-5 belonging to T7SS in M. tuberculosis. ESX-1 is the first identified ESX system and has been shown to be essential for phagosome rapture. Secreted proteins have to cross both membranes of the bacterium. ESX-1...