Alzheimer Disease (AD) is a central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. It is the major cause of dementia affecting prevalently elderly individuals worldwide. The molecular pathways underlying AD onset implicates an abnormal turnover of the Aß monomer undergoing an aggregation process to generate oligomers and protofibrils....
Permanent or temporary dental prosthesis are prepared by milling PolyMetylMetaAcrylat (PMMA) commercial discs to support patients in after mouth surgery. Impregnation of PMMA with anti inflammatory/microbial compounds derived from plant extracts such as clove oil, could improve the healing process of these patients. Impregnation of PMMA is done under different pressures and densities, as well...
The talk will present the application of an integrative structural biology approach to the field of neurotrophins. The prototype of the neurotrophin family, Nerve Growth Factor (NGF), is essential for the development and maintenance of neurons and is crucial in immune and endocrine systems and in the pain pathway. NGF precursor, proNGF, whose pro-peptide is an intrinsically unstructured domain...
The method of contact angle (CA; deg) is usually employed for the determination of surface free energy (SFE; mJ/m2) of solids and liquids (ST; mN/m). The CA method is one of the methods used in tensiometry, a non-invasive and rapid analytical approach capable of determining the surface energy properties of natural and artificial systems. The main aim of our work is the evaluation of the...
Since 2017 at IC - CNR started new research line to study the clinical use of image processing, reverse engineering and 3D printing for the introduction of innovative medical devices (MD) in pathways.
To this, an operative workshop for design and realization of personalized MD was designed and implemented. The first type of 3D printed MD was patient specifc orthopaedic cast to be used for...
The critical point of a substance represents the highest combination of temperature and pressure at which the separation between the gaseous and liquid phases remains continuous. Beyond this critical point, a state known as a supercritical fluid emerges, unifying the gaseous and liquid states and displaying properties that fall between those of gases and liquids. These distinct characteristics...
With recent technological and computational advances, structural biology has begun to address increasingly difficult questions, including complex biochemical pathways and transient interactions between macromolecules. For many years our research group has been focused on the study of the structural characteristics of different classes of proteins. In this workshop, an example of a synergistic...
Nitrogen adsorption isotherm measurement on porous materials at constant temperature 77 K and pressure ranging from 0.1 to 1000 mbar is the commonly used technique for the determination of their specific surface area and pore size distribution. Evaluation of specific surface area is done using the BET model and adsorption measurement in the pressure range 50-300 mbar, while the pore size...
