Conveners
Commercial Presentations: 1
- ALBERTO CASSETTA (Istituto di Cristallografia - Trieste)
Commercial Presentations: 2
- ALBERTO CASSETTA (Istituto di Cristallografia - Trieste)
Conventional bioassays often depend on labelling to detect biomolecular interactions and to assess protein stability. Label-free and real-time techniques are fundamental approaches for a better comprehension of structure and activity of molecules, from basic research to industry applications, allowing the analyst to get closer to the analyte and monitor it in more real conditions....
In recent years, single-particle cryo-EM has emerged as a mainstream structural biology technique which can determine the 3D structure of proteins and protein complexes at atomic resolution. However, single particle cryo-EM is limited to highly purified and isolated proteins that are averaged to determine their 3D structure and lacks a connection to the cellular context. Here,...
Interactions between biomolecules serve as key triggers for many biological processes and, therefore, provide perfect targets for therapeutics and drug discoveries. Biological binding interactions are a dynamic process driven by changes to the environment. Therefore, techniques used to characterize these interactions needs to accommodate the level of biological complexity in order to fully...
